Even where a defendant has not been charged with any sort of an obstruction offense, he can, if convicted, still have his sentence increased under section 3C1.1 of the Federal Sentencing Guidelines for "obstructing or impeding the administration of justice during the investigation, prosecution, or sentencing" of his offense of conviction. This provision is frequently used by courts to enhance the sentence of defendants found to have perjured themselves while testifying at trial.
Federal evidentiary doctrine has also been designed to deter interested parties from using force, fraud, or intimidation to keep witnesses from testifying. If a defendant, in any sort of prosecution, is found by the trial judge (using a preponderance of the evidence standard) to be responsible for a witness's absence, the defendant will be deemed to have waived his constitutional right to confrontation and his hearsay objections with respect to the missing witness. This means, for example, that statements that the witness made to the government before he disappeared can now be used against the defendant.
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